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Document ID (ISN)102148
CIS number 03-1047
ISBN(s) 3-7776-1260-X
Year 2003
Convention or series no. BUA Report 238 (Supplementary Reports IX)
Author(s)
Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Title Tributyltin oxide (No.36)
Bibliographic information S. Hirzel Wissenschaftliche Verlagsgesellachaft, P.O. Box 10 10 61, 70009 Stuttgart, Germany, 2003. xx, 108p. 220 ref. Price: EUR 49.50.
Abstract Conclusions of this criteria document on tributyltin oxide (TBTO): animal experiments show TBTO to be acutely toxic by ingestion and harmful by skin absorption. Inhaled TBTO aerosols are highly toxic. TBTO exposure is followed by rapid distribution, the main target organs being the liver, kidneys and the haematopoietic system. TBTO is immunotoxic. It is severely irritating to the skin and mucous membranes, and causes contact allergy. TBTO is not mutagenic, and is clastogenic only at cytotoxic concentrations. It does not affect fertility. In man, studies indicate that TBTO vapours cause nausea, vomiting, headaches, sore throat, irritation of the mucous membranes, and it can trigger asthma. Dermal contact with liquids containing TBTO can cause irritant skin lesions.
Descriptors (primary) Germany; toxicology; tributyltin oxide; health hazards; epidemiology
Descriptors (secondary) toxic effects; kidney; allergens; irritants; bone marrow; upper respiratory tract; liver; migraine; ingestion; inhalation; skin absorption; vomiting; harmful substances; asthma; toxic substances; aerosols; mucous membranes; animal experiments; haematotoxic effects; immunotoxic effects; criteria document; skin injuries; literature survey
Document type B - Chemical safety information sheets
Country / State or ProvinceGermany
Subject(s) Toxic and dangerous substances
Broad subject area(s)
Browse category(ies) Epidemiology