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Document ID (ISN)101705
CIS number 03-759
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2003
Convention or series no.
Author(s) Brüning T., Pesch B., Wiesenhütter B., Rabstein S., Lammert M., Baumüller A., Bolt H.M.
Title Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany
Bibliographic information Mar. 2003, Vol.43, No.3, p.274-285. 42 ref.
Abstract Findings of German studies on the relation between exposure to high levels of trichloroethylene (TRI) and renal cell cancer (RCC) are contradictory. A hospital-based case-control study with 134 RCC cases and 401 controls was conducted in order to re-evaluate the risk due to TRI in the German region of Arnsberg, which had been estimated in a previous study. Exposure was self-assessed to compare these studies. Job history was analysed using expert-based exposure information. The logistic regression results adjusted for age, sex and smoking confirmed a TRI- related RCC risk. Using the CAREX database for a comparison of industries with and without TRI exposure, a significant excess risk was estimated for the longest held job in TRI-exposing industries (odds ratio (OR) 1.80). The OR in metal degreasing activities was 5.57. Self-reported narcotic symptoms, indicative of peak exposures, were also associated with an excess risk (OR=3.71). The study supports the human nephro-carcinogenicity of trichloroethylene.
Descriptors (primary) trichloroethylene; risk factors; renal cancer
Descriptors (secondary) subjective assessment; Germany; symptoms; hazard evaluation; exposure evaluation; case-control study; frequency rates; narcotic effects; nephrotoxic effects; statistical evaluation; medical examinations; computerized data bases; hospitals
Document type D - Periodical articles
Country / State or ProvinceGermany
Subject(s) Occupational pathology
Broad subject area(s) Chemical safety
Browse category(ies) Halogenated hydrocarbons
Diseases of the kidney and the urinary system