| Document ID (ISN) | 101394 |
| CIS number |
03-292 |
| ISSN - Serial title |
0019-8366 - Industrial Health |
| Year |
2000 |
| Convention or series no. |
|
| Author(s) |
Inoue O., Kanno E., Kakizaki M., Watanabe T., Higashikawa K., Ikeda M. |
| Title |
Urinary phenylmercapturic acid as a marker of occupational exposure to benzene |
| Bibliographic information |
Apr. 2000, Vol.38, No.2, p.195-204. Illus. 35 ref. |
| Abstract |
An automated HPLC method to measure urinary phenylmercapturic acid (PMA) was developed allowing approximately 35 PMA determinations per day. It was applied to analysis of end-of-shift urine samples from 152 workers exposed up to 210ppm benzene, 66 workers exposed to a mixture of benzene (up to 116ppm) and toluene and xylenes (up to 118ppm), and 131 non-exposed controls of both sexes. A linear regression was established between time-weighted average intensity of exposure to benzene and urinary PMA, from which it was derived that urinary PMA level is approximately 6.4mg/L after 8-hour exposure to benzene at 100ppm, and that PMA in urine accounts for approximately 0.1% of benzene absorbed. No effects of sex, age and smoking habits of individuals were detected, and the effect of co-exposure to toluene and xylenes at the levels comparable to that of benzene was essentially nil, which indicates an advantage of PMA as a benzene exposure marker over mono to tri-phenolic metabolites or trans,trans-muconic acid. |
| Descriptors (primary) |
S-phenylmercapturic acid; determination in urine; exposure tests; benzene |
| Descriptors (secondary) |
toluene; trans,trans-muconic acid; description of technique; exposure evaluation; statistical evaluation; xylene |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Biological monitoring
Aromatic hydrocarbons
|
