| Document ID (ISN) | 100983 |
| CIS number |
02-1796 |
| ISSN - Serial title |
0340-0131 - International Archives of Occupational and Environmental Health |
| Year |
2002 |
| Convention or series no. |
|
| Author(s) |
Takeuchi A., Kawai T., Zhang Z.W., Miyama Y., Sakamoto K., Higashikawa K., Ikeda M. |
| Title |
Toluene, xylenes and xylene isomers in urine as biological indicators of low-level exposure to each solvent: A comparative study |
| Bibliographic information |
Aug. 2002, Vol.75, No.6, p.387-393. Illus. 29 ref. |
| Abstract |
The objective of this study was to determine if xylenes and xylene isomers in end-of-shift urine are good biological indicators of low-level exposure to each solvent, similarly to toluene in urine. 86 furniture makers (76 men and ten women), participated in the study together with 11 non-exposed controls. Time-weighted average (8h TWA) exposures to mixtures of toluene, xylenes, ethylbenzene and acetone were monitored with diffusive samplers for lipophilic and hydrophilic solvents, respectively. Urine samples were collected at the end of the shift and subjected to head-space gas chromatography analysis for each solvent. The exposure-excretion relationship was examined by simple as well as multiple regression analysis. Good correlations were found, indicating that biological monitoring of exposure by means of analysis of end-of-shift urine is possible, not only in the case of toluene as previously reported, but also in cases of xylenes, either for three isomers in combination or separately. |
| Descriptors (primary) |
toluene; solvents; furniture industry; exposure evaluation; xylene |
| Descriptors (secondary) |
acetone; ethylbenzene; p-xylene; m-xylene; o-xylene; comparative study; statistical evaluation; medical supervision; gas chromatography; determination in urine; case-control study |
| Document type |
D - Periodical articles |
| Country / State or Province | Japan |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Lumber and the woodworking industry
Exposure evaluation
Aromatic hydrocarbons
Woodworking industry
|
