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Document ID (ISN)100898
CIS number 02-1672
ISSN - Serial title 1076-2752 - Journal of Occupational and Environmental Medicine
Year 2002
Convention or series no.
Author(s) Zhai R., Liu G., Ge X., Yang C., Huang C., Wu C., Christiani D.C.
Title Genetic polymorphisms of MnSOD, GSTM1, GSTT1 and OGG1 in coal workers' pneumoconiosis
Bibliographic information Apr. 2002, Vol.44, No.4, p.372-377. 36 ref.
Abstract This study investigated the association between genetic polymorphisms of various enzymes such as MnSOD, GSTM1, GSTT1, or OGG1 and susceptibility to coal workers' pneumoconiosis (CWP). The study population was composed of 259 retired coal miners who had similar dust exposure histories. Of these, there were 99 cases with ILO chest radiological criteria for CWP and 160 controls. Individual dust exposure variables were estimated from work histories, and smoking information was obtained from interviews. Polymerase chain reaction-based techniques evaluated the genotypes of all study subjects. Logistic regression analysis revealed no differences in genotype frequency of MnSOD, GSTM1, GSTT1, and OGG1 between miners with and without CWP. Cumulative dust exposures, but not genetic polymorphisms, were associated significantly with the presence of CWP. This study illustrates the complexity of factors that may contribute to the development of CWP.
Descriptors (primary) coal dust; enzymes; coalworkers pneumoconiosis; genetic effects; coal mining; DNA
Descriptors (secondary) China; ILO; glutathione transferase; superoxide dismutase; radiological classifications; case-control study; long-term exposure; statistical evaluation; exposure evaluation
Document type D - Periodical articles
Country / State or ProvinceChina; USA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Antifertility and prenatal effects
Mining and quarrying
Genetic factors in reaction to exposures
Pneumoconioses