Document ID (ISN) | 100747 |
CIS number |
02-1651 |
ISSN - Serial title |
1076-2752 - Journal of Occupational and Environmental Medicine |
Year |
2002 |
Convention or series no. |
|
Author(s) |
Böckelmann I., Pfister E.A., McGauran N., Robra B.P. |
Title |
Assessing the suitability of cross-sectional and longitudinal cardiac rhythm tests with regard to identifying effects of occupational chronic lead exposure |
Bibliographic information |
Jan. 2002, Vol.44, No.1, p.59-65. Illus. 54 ref. |
Abstract |
The aim of this study was to examine whether signs of the neurotoxic influence of lengthy occupational lead exposure on the autonomic nervous system could be detected by cardiac rhythm analysis. A total of 109 male lead-exposed workers and 27 controls were examined in a cross-sectional study. In addition, 17 lead-exposed participants were investigated a second time in a follow-up study four years later. Heart rate variability was assessed in rest, strain and recovery phases. In the cross-sectional study, lead-exposed persons showed a delayed restoration of cardiac rhythm parameters to the initial vegetative state after the strain phase. This effect significantly increased over a period of four more years of exposure in the 17 workers participating in the follow-up study. Vagal depression caused by long-term lead exposure was found within the current threshold limit value range, but it should nonetheless be interpreted as an adverse effect. |
Descriptors (primary) |
neurotoxic effects; lead and compounds; pulse rate; sinus arrhythmia; lead |
Descriptors (secondary) |
threshold limit values; vagal reflexes; case-control study; cross-sectional study; determination in urine; liver function tests; statistical evaluation; medical examinations; long-term study |
Document type |
D - Periodical articles |
Country / State or Province | Germany |
Subject(s) |
Toxic and dangerous substances
|
Broad subject area(s) |
Chemical safety Occupational medicine, epidemiology
|
Browse category(ies) |
Cardiovascular diseases Lead and compounds Inorganic substances Diseases of the nervous system
|