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Document ID (ISN)100686
CIS number 02-1786
ISSN - Serial title 1232-1087 - International Journal of Occupational Medicine and Environmental Health
Year 2001
Convention or series no.
Author(s) Gradecka D., Palus J., Wąsowicz W.
Title Selected mechanisms of genotoxic effects of inorganic arsenic compounds
Bibliographic information 2001, Vol.14, No.4, p.317-328. Illus. 71 ref.
Internet access 02-1786.pdf [in English]
Abstract Chronic exposure to inorganic arsenic compounds is known to cause various tumours and diseases. In many regions of Asia and Latin America, the concentration of inorganic arsenic in drinking water considerably exceeds the standard of 50µg/L recommended by the US Environmental Protection Agency. The genotoxicity of inorganic arsenic has been confirmed in vitro and in vivo, as well as in examinations of exposed populations. Inorganic arsenic increases the frequency of micronuclei, chromosome aberrations and sister chromatid exchanges both in humans and in animals. Various studies suggest that inorganic arsenic may intensify the toxic effects of other physical and chemical agents, especially by DNA repair inhibition. Besides, it is believed that inorganic arsenic compounds may cause changes in the cell redox potential and alter DNA methylation and phosphorylation of cell-cycle control proteins. Some data also suggest that inorganic arsenic increases cellular proliferation and apoptosis. Possible cytotoxic mechanisms of inorganic arsenic compounds are discussed.
Descriptors (primary) toxic effects; inorganic chemicals; health hazards; genetic effects; chromosome changes; arsenic and compounds
Descriptors (secondary) literature survey; arsenic; DNA; toxicology; developing countries; in vitro experiments; cytotoxic effects; drinking water; animal experiments
Document type D - Periodical articles
Country / State or ProvincePoland
Subject(s) Toxic and dangerous substances
Broad subject area(s) Chemical safety
Browse category(ies) Inorganic substances
Genetic factors in reaction to exposures
Antifertility and prenatal effects
Arsenic and compounds