| Document ID (ISN) | 100401 |
| CIS number |
02-1346 |
| ISSN - Serial title |
0002-8894 - American Industrial Hygiene Association Journal |
| Year |
2002 |
| Convention or series no. |
|
| Author(s) |
Symanski E., Greeson N.M.H. |
| Title |
Assessment of variability in biomonitoring data using a large database of biological measures of exposure |
| Bibliographic information |
July-Aug. 2002, Vol.63, No.4, p.390-401. 102 ref. |
| Abstract |
Biological monitoring data that examined workers' exposures to metals, solvents, polycyclic aromatic hydrocarbons and pesticides were collected from 53 published studies. This study evaluates intra- and inter-individual sources of variation in biological measures of exposure collected from workers employed at the same plant. In 60% of the data sets, there was more variation among workers than variation from day to day. The relative magnitude of the intra- to inter-individual source of variation was larger for biomarkers with short compared to long half-lives, which suggests that biomarkers with half-lives of seven days or longer offer advantages when compared to short-lived biomarkers or exposures assessed by air monitoring. The use of biological indices of exposure, however, places an additional burden on the strategy used to evaluate exposures, because data may be serially correlated, resulting in biased estimates of the variance components if autocorrelation is undetected or ignored in the statistical analyses. |
| Descriptors (primary) |
exposure evaluation; subject variability; determination in biological matter; statistical evaluation; sampling and analysis |
| Descriptors (secondary) |
literature survey; data processing; safety and health documentation; exposure tests; evaluation of results |
| Document type |
D - Periodical articles |
| Country / State or Province | USA |
| Subject(s) |
Toxic and dangerous substances
|
| Broad subject area(s) |
Chemical safety
|
| Browse category(ies) |
Statistical methods
Exposure evaluation
|
