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CISDOC database

Document ID (ISN)100145
CIS number 02-1226
ISSN - Serial title 0271-3586 - American Journal of Industrial Medicine
Year 2001
Convention or series no.
Author(s) Yucesoy B., Vallyathan V., Landsittel D.P., Sharp D.S., Matheson J., Burleson F., Luster M.I.
Title Polymorphisms of the IL-1 gene complex in coal miners with silicosis
Bibliographic information Mar. 2001, Vol.39, No.3, p.286-291. 28 ref.
Abstract Pro-inflammatory cytokines, such as interleukin-1 (IL-1), play a role in the development of silicosis. The study compared 318 histopathologically confirmed pulmonary silicosis patients with controls. Genotyping was carried out through the polymerase chain reaction technique. The proportion of the IL-1 receptor antagonist (allele 2 genotype) was higher in miners with silicosis than in controls. This is the first report suggesting that such a genetic polymorphism may confer an increased risk for the development of the disease.
Descriptors (primary) silicosis; coal mining; cytological effects
Descriptors (secondary) genetic screening
Document type D - Periodical articles
Country / State or ProvinceTurkey; USA
Subject(s) Occupational pathology
Broad subject area(s) Occupational medicine, epidemiology
Browse category(ies) Mining and quarrying
Pneumoconioses